Facts of Autism Found in Peer-Reviewed Journals

Facts of Autism Found in Peer-Reviewed Journals

Scientific findings on inflammation, blood flow, and intestinal permeability in autism.

1. Inflammation

hs-CRP inflammation levels in autistic children are extreme:

  • “Normal range”: <1.0 ng/mL
  • “Heart disease risk”: >3 ng/mL
  • “Autoimmune disease”: 20-80 ng/mL
  • Autism: 500+ ng/mL (extreme cases >1000 ng/mL)

2. Cerebral Blood Flow

Blood flow reductions in autistic children:

  • Frontal lobes: -42.7%
  • Basal nucleus: -24.9%
  • Temporal lobe: -22.8%

3. Intestinal Permeability

43% of autistic children (9/21) show abnormal permeability. This allows undigested food particles, toxins, and bacteria to leak into bloodstream, triggering immune response and red blood cell clumping (Rouleaux formations).

Key Pathophysiology Chain

  1. Increased intestinal permeability →
  2. Immune activation →
  3. Red blood cell aggregation →
  4. Decreased cerebral blood flow

Autism Prevalence & Current Challenges

Current U.S. rate: 1 in 31 births. No objective diagnostic tests/treatments in standard care. FDA-approved medications only address behavioral symptoms: Risperidone (Ages 5-16) and Aripiprazole (Ages 6-17).

Scientific References

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