Incorporating CRP and Lp-PLA2 into Annual Physical Examinations

Executive Summary

Cardiovascular disease remains the leading cause of mortality worldwide, with myocardial infarction and stroke accounting for significant morbidity and healthcare costs. This white paper proposes incorporating C-Reactive Protein (CRP) and Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) testing into routine annual physical examinations as evidence-based biomarkers for enhanced cardiovascular risk assessment.

These inflammatory biomarkers provide critical information beyond traditional lipid panels and can identify at-risk individuals who might otherwise be missed by conventional screening methods. The integration of these tests into standard practice represents a paradigm shift toward proactive, prevention-focused cardiovascular care.

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